منابع مشابه
Clinical relevance of acute mixed-lineage leukemia.
A recent report by Pui et all focused on the biologic and clinical relevance of acute mixed-lineage leukemia; namely, acute lymphoblastic leukemia expressing myeloid-associated antigens (My+ ALL) and acute myeloid antigens expressing lymphoid antigens (Ly+ AML) were analyzed in a pediatric series. In our opinion, a major point in the field of hybrid acute leukemia remaining undetermined is whic...
متن کاملClinical Relevance of Acute Mixed-lineage Leukemia
A recent report by Pui et all focused on the biologic and clinical relevance of acute mixed-lineage leukemia; namely, acute lymphoblastic leukemia expressing myeloid-associated antigens (My+ ALL) and acute myeloid antigens expressing lymphoid antigens (Ly+ AML) were analyzed in a pediatric series. In our opinion, a major point in the field of hybrid acute leukemia remaining undetermined is whic...
متن کاملThe molecular biology of mixed lineage leukemia.
Mixed lineage leukemia is a very aggressive blood cancer that predominantly occurs in pediatric patients. In contrast to other types of childhood acute leukemias, mixed lineage leukemia presents with a dismal prognosis and despite the availability of advanced treatment methods cure rates have stagnated over the last years. Mixed lineage leukemia is characterized by the presence of MLL fusion pr...
متن کاملMisguided Transcriptional Elongation Causes Mixed Lineage Leukemia
Fusion proteins composed of the histone methyltransferase mixed-lineage leukemia (MLL) and a variety of unrelated fusion partners are highly leukemogenic. Despite their prevalence, particularly in pediatric acute leukemia, many molecular details of their transforming mechanism are unknown. Here, we provide mechanistic insight into the function of MLL fusions, demonstrating that they capture a t...
متن کاملMixed lineage leukemia translocations and a leukemia stem cell program.
Cancer stem cells (CSC) may provide the self-renewal capacity required to sustain a tumor. One possibility is that CSC arise from the stem cell counterparts in normal tissues. Alternatively, CSC may arise from more differentiated progenitor cells found in certain tissues. In support of this idea, we showed recently that mixed lineage leukemia fusion oncoproteins can convert committed hematopoie...
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ژورنال
عنوان ژورنال: International Journal of Hematologic Oncology
سال: 2013
ISSN: 2045-1393,2045-1407
DOI: 10.2217/ijh.13.20